The stress begins on Day 1 for the Cincinnati Bengals after they journey to Cleveland to open the 2025 NFL common season on Sunday. Cincinnati didn’t make the playoffs final 12 months regardless of a near-MVP 12 months by quarterback Joe Burrow. The Bengals, who closed 2024 by successful their closing 5 video games, will face a Cleveland Browns group that named Joe Flacco its Week 1 starter. The Bengals are 5.5-point favorites, however Burrow is simply 3-5 in his profession versus Cleveland, whereas Flacco hasn’t confronted Cincy since 2022.
Dolphins vs. Colts (-1) has the bottom Week 1 NFL unfold as Daniel Jones will make his group debut towards Tua Tagovailoa and Miami. Different slim NFL traces embrace Buccaneers vs. Falcons (+1.5) and 49ers vs. Seahawks (+1.5). Which group has worth to incorporate in Week 1 NFL bets, and which aspect of the NFL odds do you have to goal? Earlier than locking in any Week 1 NFL picks or NFL parlays, be sure you see the NFL predictions and betting recommendation from SportsLine’s confirmed pc mannequin.
The mannequin, which simulates each NFL recreation 10,000 occasions, is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin went 31-15 on top-rated picks in 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites may have seen sturdy returns.
Now, the mannequin has scoured the Week 1 NFL odds and locked in 5 assured NFL greatest bets. In the event you efficiently parlay its sports activities betting picks, you would be taking a look at an enormous payout of practically 25-1. You possibly can solely see the mannequin’s Week 1 NFL picks at SportsLine,
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Prime Week 1 NFL picks
After simulating each recreation 10,000 occasions, the mannequin is excessive on the Washington Commanders (-6.5, 45.5) to cowl towards the New York Giants. Washington reached the NFC Championship Sport final season. The Commanders had received seven consecutive video games going into that recreation behind Jayden Daniels, now in his second season. Daniels was dominant in 2024. He accomplished 69% of his passes for 3,568 yards, 25 touchdowns with simply 9 interceptions. In a 45-31 divisional spherical win over the Detroit Lions, Daniels accomplished 22 of 31 passes for 299 yards and two touchdowns with zero interceptions.
After some drama involving his contract, prime receiver Terry McLaurin now has a brand new deal as properly, placing him place to be within the lineup for the opener. The Commanders received each conferences final season, and the mannequin has them masking in additional than 60% of simulations in an A-rated decide. See which different NFL parlay picks to make right here and guess the Commanders to cowl right here:
The way to make Week 1 NFL parlays
The mannequin additionally jumped on 4 different NFL matchups the place it says the road is approach off, together with backing an underdog that it says is not going to solely cowl, however win outright. You possibly can solely see the mannequin’s Week 1 NFL greatest bets and NFL parlay at SportsLine.
What are the mannequin’s prime Week 1 NFL picks, and which NFL matchups do you have to goal for an epic 25-1 payout? Go to SportsLine now to see the Week 1 NFL greatest bets from a mannequin on an 31-15 run on top-rated picks, and discover out.
