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NFL longshot picks, Week 1 2025 odds, props: This parlay might pay over $4,000 on a $10 wager

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Last updated: August 30, 2025 7:14 pm
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NFL longshot picks, Week 1 2025 odds, props: This parlay might pay over ,000 on a  wager
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High Week 1 NFL parlay picksThe best way to make NFL parlay picks for a payout of over $4k

The Week 1 NFL schedule is approaching and the league has once more unfold it out over 4 totally different days. The newest Week 1 NFL odds checklist the Eagles at -7.5 towards the Cowboys within the 2025 NFL Kickoff Sport on Thursday, Sept. 4. The Chiefs are -3 towards the Chargers in Brazil on Friday. 13 different video games are set for that Sunday, with Bears (-1.5) vs. Vikings concluding the slate on Monday Night time Soccer. 

Successfully constructing NFL parlay picks can repay massive in your NFL betting technique. NFL parlays include a a lot better threat than straight bets, however additionally they carry the potential of a a lot greater reward. Earlier than making any Week 1 NFL picks and parlays, you should see the Week 1 NFL longshot parlay from SportsLine’s confirmed laptop simulation mannequin that pays out nicely over $4,000 on a $10 wager. You possibly can wager this NFL parlay utilizing the most recent DraftKings promo code, which provides $300 in bonus bets immediately plus over $200 off NFL Sunday Ticket:

The mannequin, which simulates each NFL sport 10,000 occasions, is up nicely over $7,000 for $100 gamers on top-rated NFL picks its since inception. The mannequin went 31-15 on top-rated picks in 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen sturdy returns.

Now that the simulation mannequin has had an opportunity to digest the Week 1 NFL odds, it is locked in its betting picks to type a 5-leg NFL parlay that would pay out over $4,000 for a $10 bettor. You possibly can solely see the picks and full parlay by heading to SportsLine.

High Week 1 NFL parlay picks

For Week 1, one of many mannequin’s parlay picks is backing the Buccaneers on the alternate line of -7.5 towards the Falcons, a wager that returns +255. The usual unfold is Bucs -2.5, however the mannequin has noticed a chance to go a lot greater right here. 

The Bucs are projected to win almost 70% of the time and the mannequin’s successful margin is 8 factors, leaving loads of room to play alternate strains. Tampa Bay returns its explosive offensive core, and even drafted Emeka Egbuka to bolster a robust group of receivers for quarterback Baker Mayfield.

Tampa Bay was additionally elite defensively late within the 2024 season, permitting simply 17 factors per sport within the closing seven video games of the season. Atlanta has extra query marks total, and SportsLine’s mannequin likes Tampa Bay’s possibilities of occurring the street and grabbing a giant season-opening win. See the remainder of the picks within the Week 1 NFL parlay right here, and new customers can try the most recent bet365 bonus code to get $200 in bonus bets after putting a $5 wager:

The best way to make NFL parlay picks for a payout of over $4k

The parlay additionally contains 4 further picks from SportsLine’s laptop mannequin, together with an anytime landing scorer wager that returns +500. You possibly can solely see the picks and the complete parlay at SportsLine.

What are the highest NFL picks for Week 1 that may be mixed right into a parlay that returns over $4,000 on only a $10 wager? And what optimum landing scorer wager returns +500? Go to SportsLine now to see the highest Week 1 NFL picks from SportsLine’s confirmed simulation mannequin that may be mixed for a parlay that pays nicely over $4,000, and discover out.



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