2025 NFL Odds Week 3: Strains, Spreads for all 16 Video games

Week 2 will be in the running for best early-afternoon slate of the year.

Now, Week 3 kicks off Thursday night, as the Buffalo Bills host the Miami Dolphins.

Here are the lines for every Week 3 matchup at DraftKings Sportsbook as of Sept. 14.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

(All times ET)

2025 NFL Week 3 Odds

THURSDAY, SEPT. 18

DOLPHINS @ BILLS (8:15 p.m., Prime Video)

Point spread: Bills -12.5 (Bills favored to win by 12.5 points or more, otherwise Dolphins cover)
Moneyline: Bills -675 favorites to win (bet $10 to win $11.48 total); Dolphins +490 underdogs to win (bet $10 to win $59 total)
Total Over/Under: 49.5 points scored by both teams combined

SUNDAY, SEPT. 21

PACKERS @ BROWNS (1:00 p.m., FOX)

Point spread: Packers -8.5 (Packers favored to win by 8.5 points or more, otherwise Browns cover)
Moneyline: Packers -410 favorites to win (bet $10 to win $12.44 total); Browns +320 underdogs to win (bet $10 to win $42 total)
Total Over/Under: 41.5 points scored by both teams combined

COLTS @ TITANS (1:00 p.m., CBS)

Point spread: Colts -3 (Colts favored to win by 3 points or more, otherwise Titans cover)
Moneyline: Colts -155 favorites to win (bet $10 to win $16.45 total); Titans +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 43.5 points scored by both teams combined

BENGALS @ VIKINGS (1:00 p.m., CBS)

Point spread: Vikings -4.5 (Vikings favored to win by 4.5 points or more, otherwise Bengals cover)
Moneyline: Vikings -205 favorites to win (bet $10 to win $14.88 total); Bengals +170 underdogs to win (bet $10 to win $27 total)
Total Over/Under: 43.5 points scored by both teams combined

STEELERS @ PATRIOTS (1:00 p.m., CBS)

Point spread: Steelers -1.5 (Steelers favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Steelers -115 favorites to win (bet $10 to win $18.70 total); Patriots -105 underdogs to win (bet $10 to win $19.52 total)
Total Over/Under: 44.5 points scored by both teams combined

Tom Brady breaks down Eagles’ win over Chiefs

RAMS @ EAGLES (1:00 p.m., FOX)

Point spread: Eagles -4.5 (Eagles favored to win by 4.5 points or more, otherwise Rams cover)
Moneyline: Eagles -225 favorites to win (bet $10 to win $14.44 total); Rams +185 underdogs to win (bet $10 to win $28.50 total)
Total Over/Under: 45.5 points scored by both teams combined

JETS @ BUCCANEERS (1:00 p.m., FOX)

Point spread: Buccaneers -7 (Buccaneers favored to win by 7 points or more, otherwise Jets cover)
Moneyline: Buccaneers -305 favorites to win (bet $10 to win $13.28 total); Jets +245 underdogs to win (bet $10 to win $34.50 total)
Total Over/Under: 45.5 points scored by both teams combined

RAIDERS @ COMMANDERS (1:00 p.m., FOX)

Point spread: Commanders -6.5 (Commanders favored to win by 6.5 points or more, otherwise Raiders cover)
Moneyline: Commanders -278 favorites to win (bet $10 to win $13.60 total); Raiders +225 underdogs to win (bet $10 to win $32.50 total)
Total Over/Under: 47.5 points scored by both teams combined

FALCONS @ PANTHERS (1:00 p.m., FOX)

Point spread: Falcons -3.5 (Falcons favored to win by 3.5 points or more, otherwise Panthers cover)
Moneyline: Falcons -180 favorites to win (bet $10 to win $15.56 total); Panthers +150 underdogs to win (bet $10 to win $25 total)
Total Over/Under: 44.5 points scored by both teams combined

TEXANS @ JAGUARS (1:00 p.m., CBS)

Point spread: Jaguars -1.5 (Jaguars favored to win by 1.5 points or more, otherwise Texans cover)
Moneyline: Jaguars -115 favorites to win (bet $10 to win $18.70 total); Texans -105 underdogs to win (bet $10 to win $19.52 total)
Total Over/Under: 44.5 points scored by both teams combined

BRONCOS @ CHARGERS (4:05 p.m., CBS)

Point spread: Chargers -2.5 (Chargers favored to win by 2.5 points or more, otherwise Broncos cover)
Moneyline: Chargers -142 favorites to win (bet $10 to win $17.04 total); Broncos +120 underdogs to win (bet $10 to win $22 total)
Total Over/Under: 45.5 points scored by both teams combined

SAINTS @ SEAHAWKS (4:05 p.m., CBS)

Point spread: Seahawks -7.5 (Seahawks favored to win by 7.5 points or more, otherwise Saints cover)
Moneyline: Seahawks -345 favorites to win (bet $10 to win $12.90 total); Saints +275 underdogs to win (bet $10 to win $37.50 total)
Total Over/Under: 42.5 points scored by both teams combined

COWBOYS @ BEARS (4:25 p.m., FOX)

Point spread: Bears -1.5 (Bears favored to win by 1.5 points or more, otherwise Cowboys cover)
Moneyline: Bears -120 favorites to win (bet $10 to win $18.33 total); Cowboys +100 underdogs to win (bet $10 to win $20 total)
Total Over/Under: 48.5 points scored by both teams combined

CARDINALS @ 49ERS (4:25 p.m., FOX)

Point spread: Cardinals -1.5 (Cardinals favored to win by 1.5 points or more, otherwise 49ers cover)
Moneyline: Cardinals -118 favorites to win (bet $10 to win $18.47 total); 49ers -102 underdogs to win (bet $10 to win $19.80 total)
Total Over/Under: 43.5 points scored by both teams combined

CHIEFS @ GIANTS (8:20 p.m., NBC)

Point spread: Chiefs -5.5 (Chiefs favored to win by 5.5 points or more, otherwise Giants cover)
Moneyline: Chiefs -250 favorites to win (bet $10 to win $14 total); Giants +205 underdogs to win (bet $10 to win $30.50 total)
Total Over/Under: 42.5 points scored by both teams combined

MONDAY, SEPT. 22

LIONS @ RAVENS (8:15 p.m., ABC/ESPN)

Point spread: Ravens -6 (Ravens favored to win by 6 points or more, otherwise Lions cover)
Moneyline: Ravens -258 favorites to win (bet $10 to win $13.88 total); Lions +210 underdogs to win (bet $10 to win $31 total)
Total Over/Under: 51.5 points scored by both teams combined

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!

What did you consider this story?