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Week 3 NFL odds, strains, betting picks, spreads: 2025 predictions: Mannequin backs Packers, Colts

Madisony
Last updated: September 16, 2025 12:13 pm
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Week 3 NFL odds, strains, betting picks, spreads: 2025 predictions: Mannequin backs Packers, Colts
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Prime Week 3 NFL predictionsHow to make Week 3 NFL picksWeek 3 NFL betting odds, lines, live spreads, scores   

The Week 3 NFL schedule has an attention-grabbing mix of divisional rivalries and cross-conference showdowns. The previous has Broncos vs. Chargers, with L.A. 2.5-point residence favorites within the Week 3 NFL odds, whereas 49ers vs. Cardinals has San Fran favored by 1.5 factors. Then, there are contests like Bengals vs. Vikings (-3.5), Chiefs vs. Giants (+5.5) and Ravens vs. Lions (+6) These AFC vs. NFC matchups are fairly uncommon, thus presumably giving them a bit extra attraction to make Week 3 NFL predictions on.

A few weeks beneath the belt additionally provides sportsbooks a clearer image into how good, or unhealthy, groups are. In consequence, there are wider NFL spreads this week, with 4 video games having a line of at the least a landing. Must you again large favorites just like the Bucs (-7) versus the Jets or the Seahawks (-7.5) towards the Saints with Week 3 NFL bets? 

The entire up to date Week 3 NFL strains are listed under, and SportsLine’s superior laptop mannequin has all of the NFL betting recommendation and NFL predictions you want to make the very best Week 3 NFL picks now. 

Guess on each NFL Week 3 recreation at DraftKings Sportsbook, the place new customers can goal the DraftKings promo code, which gives $200 in bonus bets immediately plus over $200 off NFL Sunday Ticket:

The mannequin, which simulates each NFL recreation 10,000 instances, is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin is on a 37-17 run on top-rated picks relationship again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen robust returns.

Now, it has turned its consideration to the newest Week 3 NFL odds and NFL betting strains and locked in betting picks for each NFL matchup. Head right here to see each choose. 

New customers may take a look at the newest FanDuel promo code and get $300 in bonus bets immediately at FanDuel in case your $5 wager wins:

Prime Week 3 NFL predictions

We will inform you one of many mannequin’s strongest Week 3 NFL picks is that the Packers (-8.5, 42.5) cowl the unfold at Cleveland in a Sunday 1 p.m. ET kickoff. Inexperienced Bay could have the remainder benefit after defeating Washington final Thursday, and the Packers even have the unfold benefit. The Pack are 2-0 towards the unfold (ATS) this 12 months and have coated in seven of the final eight common season video games began and completed by Jordan Love.

In the meantime, the Browns are 5-14 ATS because the begin of final season, which is the second-worst unfold mark within the NFL. This 12 months’s Browns group has appeared similar to previous ones, with struggles on either side of the ball. No group has a worst turnover differential (-4) than Cleveland, which ranks within the backside eight in each scoring offense and scoring protection. The mannequin has Inexperienced Bay successful by two touchdowns and prevailing versus the unfold over 60% of the time. See which different groups to select right here.

Another one of its Week 3 NFL predictions: the Colts (-3, 43.5) cover at Tennessee in well over 50% of simulations. Daniel Jones’ arrival has invigorated the entire Colts offense as it has been historic thus far. Indy is the first team in NFL history to not punt in either of its first two games, despite the Colts just taking on one of the league’s best defenses in the Broncos in Week 2. The Colts rank in the top four in all of the major offensive categories: points scored, yards gained, rushing offense and passing offense.

As for Tennessee, it has looked every bit like a team that was deserving of the No. 1 overall pick in the NFL Draft. That pick, Cam Ward, has been sacked a league-high of 11 times as Tennessee has scored just one touchdown and ranks 31st in points per game. Ward is projected to be taken down at least three times on Sunday, while also committing a turnover, as the Colts cover on the road. The model also says the Over hits almost 70% of the time. See which other teams to pick here.

How to make Week 3 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 3 NFL schedule and just revealed four coveted A-rated spread picks, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 3 NFL betting odds, lines, live spreads, scores

Get Week 3 NFL picks at SportsLine

   

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