The Week 5 NFL schedule contains a compelling slate of matchups throughout the league, highlighted by a number of key video games that might assist form the NFL playoff image. The Minnesota Vikings (-3.5, 36.5) will face the Cleveland Browns in London, kicking off Sunday’s motion at 9:30 a.m. ET. The Dallas Cowboys (-2.5, 47.5) will tackle the New York Jets, whereas the Denver Broncos go to the Philadelphia Eagles (-3.5, 43.5) in a matchup that might have important playoff implications. Different notable video games embrace the Houston Texans (-2.5, 39.5) visiting the Baltimore Ravens, and the New York Giants heading to New Orleans to face the Saints (-1.5, 40.5). Within the afternoon window, the Detroit Lions (-10, 49.5) will battle the Cincinnati Bengals, and the Tampa Bay Buccaneers hit the street to tackle the Seattle Seahawks (-3.5, 44.5). The week concludes with a Monday Evening Soccer showdown between the Kansas Metropolis Chiefs (-3.5, 46.5) and the Jacksonville Jaguars.
Successfully constructing NFL parlay picks can repay huge in your NFL betting technique. NFL parlays include a a lot higher danger than straight bets, however in addition they carry the potential of a a lot greater reward. Earlier than making any Week 5 NFL picks and parlays, it’s good to see the Week 5 NFL longshot parlay from SportsLine’s confirmed laptop simulation mannequin that pays out effectively over $14,000 on a $10 wager.
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The mannequin, which simulates each NFL recreation 10,000 occasions, is up effectively over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin is on a scorching 39-19 run on top-rated picks relationship again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen sturdy returns.
Now that the simulation mannequin has had an opportunity to digest the Week 5 NFL odds, it is locked in its betting picks to type a 5-leg NFL parlay that might pay out effectively over $8,000 for a $10 bettor. You possibly can solely see the picks and full parlay by heading to SportsLine.
High Week 5 NFL parlay picks
For Week 5, one of many mannequin’s parlay picks is backing the Lions on the alternate line of -14.5 towards the Bengals, a wager that returns +40. The usual unfold is Lions -10, however the mannequin has noticed a chance to go a lot greater right here.
The Lions are projected to win 78% of the time, and the mannequin’s successful margin is 15 factors, leaving loads of room to play alternate strains. The Lions bounced again from a tricky loss in Week 1 to file three straight spectacular victories, together with a 34-10 win over the Browns in Week 4. In the meantime, the Bengals are struggling to get issues going with Joe Burrow out of the lineup. Cincinnati is coming off a 28-3 loss to the Broncos on Monday Evening Soccer in Week 4.
The Detroit offense is powered by quarterback Jared Goff, who has thrown for 929 yards and 9 touchdowns with simply two interceptions in 2025. The previous No. 1 total decide has performed himself into the early season NFL MVP dialog. Working again Jahmyr Gibbs continues to be a dynamic pressure with 271 dashing yards and 4 dashing touchdowns, and 20 catches for 79 yards. Broad receiver Amon-Ra St. Brown has recorded 307 receiving yards and 6 touchdowns on 27 receptions.
Defensively, edge rusher Aidan Hutchinson has tallied 4 sacks and eight tackles with two pressured fumbles by the primary 4 video games of the 2025 season. See the remainder of the picks within the Week 5 NFL parlay right here.
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The best way to make NFL parlay picks for a payout of effectively over $14,000
The parlay additionally contains 4 extra picks from SportsLine’s laptop mannequin, together with a primary landing scorer prop wager that returns +1100. You possibly can solely see the picks and the complete parlay at SportsLine.
What are the highest NFL picks for Week 5 that may be mixed right into a parlay that returns effectively over $14,000 on only a $10 wager? And what optimum first landing scorer wager returns +1100? Go to SportsLine now to see the highest Week 5 NFL picks from SportsLine’s confirmed simulation mannequin that may be mixed for a parlay that pays effectively over $14,000, and discover out.
