Philadelphia’s Saquon Barkley’s record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.
But that was last season.
Could the Philly star be upended at the conclusion of this NFL campaign?
Let’s check out the odds at DraftKings Sportsbook as of Sept. 30, as well as what to know about each leading candidate.
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2025-26 Offensive Player of the Year
Puka Nacua, WR, Rams: +300
What to know: L.A.’s Puka Nacua is the new favorite for Offensive Player of the Year. He has the most receptions (42) and receiving yards (503) in the NFL through four weeks. The Rams are 3-1, and despite DaVante Adams joining the squad, Nacua has established himself as the team’s true No. 1 receiver. His odds surged from +850 after having a 170-yard receiving day in the Rams’ Week 4 win over the Colts.
Jonathan Taylor, RB, Colts: +450
What to know: Colts’ workhorse running back Jonathan Taylor has helped the team reach their surprising 3-1 record. His 414 yards on the ground are a league-best, and his three TDs are tied for sixth-best in the NFL.
Bijan Robinson, RB, Falcons: +500
What to know: Through four weeks, Robinson has 314 rushing yards and 270 receiving yards — a true-dual threat back. But after his 75-yard rushing, 106-yard receiving Week 4 performance in the Falcons’ win over Washington, his odds surged to +500 from +1000.
Christian McCaffrey, RB, 49ers: +600
What to know: It’s business as usual for dual-threat back McCaffrey. He has 225 rushing yards and 305 receiving yards through four weeks for the 3-1 49ers.
Amon-Ra St. Brown, WR, Lions: +1500
What to know: Brown’s 27 receptions are tied for fourth in the NFL and his six TDs are best in the league. He also has 307 receiving yards on the season (seventh).
James Cook, RB, Bills: +1500
What to know: James is, in fact, cooking for the undefeated Bills this year. His 401 rushing yards rank second in the league, his five touchdowns rank first and he has 75 carries (fourth).
Jahmyr Gibbs, RB, Lions: +1600
What to know: Gibbs, like St. Brown, is helping give Detroit’s offense a boost. He’s got four TDs and 271 rushing yards so far this season.
Derrick Henry, RB, Ravens: +2500
What to know: After a dominant Week 1 performance against Buffalo (169 rushing yards, two TDs), Henry has struggled. Through Weeks 2 and 3, he had 73 combined rushing yards and one touchdown. Most glaringly, he has three fumbles on the season, and two of those were for loss — including costly ones in the Week 1 loss to Buffalo and the Week 3 loss to Detroit. Over the last week, he’s dropped from +1100 in this spot.
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