Acquainted matchups abound on the NFL Week 10 schedule as there are half a dozen divisional video games you may make Week 10 NFL picks on. The spotlight of that slate is Rams vs. 49ers, which has L.A. because the 5.5-point highway favourite, per the newest NFL odds. The Niners received, 26-23, when the 2 met in early October, however the Rams had received the three prior matchups. That is considered one of 5 video games with a Week 10 NFL unfold that favors the highway group, with the Browns flipped from highway underdogs to favorites (-2.5) in opposition to the Jets after New York traded away star defenders Sauce Gardner and Quinnen Williams earlier than the commerce deadline on Tuesday.
Different divisional contests embrace Payments vs. Dolphins (+9), which has the widest line of the day, Saints vs. Panthers (-5.5) and Texans vs. Jaguars (+1.5), with each C.J. Stroud (concussion) and Brian Thomas Jr. (ankle) sidelined. The non-divisional slate is highlighted by Steelers vs. Chargers (-2.5) on Sunday evening, because the groups have alternated wins and losses over their final six, and Eagles vs. Packers (-1.5) on Monday evening, with Philly profitable every of the final three conferences. All the up to date Week 10 NFL strains are listed under, and SportsLine’s superior laptop mannequin has all of the NFL betting recommendation and NFL predictions you have to make one of the best Week 10 NFL picks now.
LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.
New customers also can goal the DraftKings promo code, which affords $300 in bonus bets in case your preliminary $5 guess wins + 3 months of NBA League Go:
The mannequin, which simulates each NFL recreation 10,000 occasions, is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin enters Week 10 on a scorching 47-29 run on top-rated picks relationship again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen sturdy returns.
Now, it has turned its consideration to the newest Week 10 NFL odds and NFL betting strains and locked in betting picks for each NFL matchup. Head right here to see each choose.
New customers also can take a look at the newest FanDuel promo code and get $300 in bonus bets immediately at FanDuel in case your $5 guess wins:
Prime Week 10 NFL predictions
We are able to inform you one of many mannequin’s strongest Week 10 NFL picks is that the Bucs (-2.5, 48) cowl at house versus the Patriots in a Sunday 1 p.m. ET kickoff. New England prolonged its win streak to 6 video games on Sunday versus Atlanta, however the Pats did not cowl for the primary time throughout the streak. In the meantime, the Bucs coated their final trip and have the remaining benefit in coming off a Week 9 bye. That benefit for Tampa — and drawback for New England — cannot be missed because the Pats are 4-12-1 ATS over their final 17 with a relaxation drawback, which dates again to the Tom Brady period.
With that ATS loss to the Falcons, New England is barely 3-9-1 ATS versus NFC opponents since 2023. On the sector, the Patriots have the NFL’s worst redzone protection this season, and Drake Maye has been sloppy with the ball as of late. He has three fumbles (one misplaced) and two interceptions over his final two video games, which Tampa can capitalize on because it boasts the fourth-best turnover differential (+7) within the league. With the mannequin projecting the Bucs to win the turnover battle on Sunday, and racking up twice as many defensive sacks, Tampa prevails versus the unfold properly over 50% of the time. See which different groups to select right here.
Another one of its Week 10 NFL predictions: 49ers (+5.5, 49.5) cover versus the Rams in well over 50% of simulations. San Francisco is 8-4 versus the spread over these teams last dozen meetings, including outright winning as 8.5-point underdogs in Week 5. The Niners are coming off a double-digit road victory over the Giants with Mac Jones under center. Jones will get another start on Sunday, though Brock Purdy (toe) could be active. It hasn’t mattered a ton who is at quarterback for the team as long as Christian McCaffrey is at running back. He set an NFL record on Sunday with his 16th game with both a rushing and receiving touchdown as he leads the NFL with 1,222 yards from scrimmage.
Los Angeles has only truly been tested in a road environment just once this season, and it lost at Philadelphia. The team’s other true road games include facing the Ravens without Lamar Jackson, and facing the lowly Titans. While L.A. has impressive metrics on both sides of the ball, one can’t overlook its subpar special teams. The Rams are last in field goal percentage, third-worst in extra point percentage and just seven teams give up more yards per punt return. With San Fran having the edge on the margins, it covers, and the model also says the Under hits well over 60% of the time in an A-rated total pick. See which other teams to pick here.
How to make Week 10 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 10 NFL schedule and just revealed four teams that cover in 60% of simulations or more, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 10 NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 10 NFL betting odds, lines, live spreads, scores
