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Notre Dame vs. Pittsburgh odds, line, picks: Week 12 picks from 10,000 simulations

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Last updated: November 15, 2025 3:31 am
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Notre Dame vs. Pittsburgh odds, line, picks: Week 12 picks from 10,000 simulations
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The Tenth-ranked Notre Dame Combating Irish battle the Twenty fourth-ranked Pittsburgh Panthers in a key non-conference matchup on Saturday afternoon. Notre Dame is coming off a 49-10 win over Navy final Saturday, whereas Pitt downed Stanford 35-20 on Nov. 1. The Combating Irish (7-2), who’ve gained seven in a row, are 2-1 on the highway this season. The Panthers (7-2), who’re tied for the Atlantic Coast Convention lead at 5-1, have gained 5 in a row and are 4-1 on their residence discipline.

Kickoff from Acrisure Stadium in Pittsburgh is at midday ET. Notre Dame leads the all-time collection 51-21-1, together with a 28-11-1 edge in video games performed in Pittsburgh. The Combating Irish are 12.5-point favorites within the newest Notre Dame vs. Pittsburgh odds, whereas the over/underneath for whole factors scored is 54.5 by way of SportsLine consensus. Earlier than making any Notre Dame vs. Pittsburgh picks, take a look at the faculty soccer predictions from the SportsLine Projection Mannequin. 

New customers can goal the DraftKings promo code, which affords $300 in bonus bets in case your guess wins + 3 months of NBA League Go:

The mannequin simulates each FBS recreation 10,000 occasions. Since its inception, it has generated a betting revenue of over $2,000 for $100 gamers on its top-rated faculty unfold soccer picks. Anyone following its faculty soccer betting picks at sportsbooks and on betting websites might have seen sturdy returns.

Now, the mannequin has set its sights on Notre Dame vs. Pittsburgh. You’ll be able to go to SportsLine now to see the picks. Listed below are the FBS faculty soccer odds and developments for Pitt vs. Notre Dame:

Notre Dame vs. Pittsburgh unfold

Notre Dame -12.5 at DraftKings Sportsbook

Notre Dame vs. Pittsburgh over/underneath

54.5 factors

Notre Dame vs. Pittsburgh cash line 

Notre Dame -457, Pittsburgh +351

Notre Dame vs. Pittsburgh picks

See picks at SportsLine

Notre Dame vs. Pittsburgh streaming 

Fubo (Attempt without spending a dime)  

New customers also can take a look at the newest FanDuel promo code and get $150 in bonus bets at FanDuel in case your $5 guess wins. 

Tips on how to make Notre Dame vs. Pittsburgh picks

SportsLine’s mannequin is going over on the overall (54.5). The Over has hit in six of the final 10 Notre Dame video games, whereas the Over has hit in seven of the previous 10 Pittsburgh video games. The mannequin tasks Combating Irish quarterback C.J. Carr to throw for greater than 250 yards and two touchdowns, whereas operating again Jeremiyah Love will rush over 15 occasions for almost 100 yards and a rating. 

Panthers quarterback Mason Heintschel is projected to throw for greater than 200 yards and multiple landing. The groups additionally mix for 58 factors because the Over clears in over 50% of simulations. 

The mannequin additionally says one facet of the unfold hits almost 70% of the time. You’ll be able to solely get that decide at SportsLine. 

So who wins Notre Dame vs. Pittsburgh, and which facet of the unfold hits almost 70% of the time? Go to SportsLine now to see which facet of the Notre Dame vs. Pittsburgh unfold to leap on, all from the superior mannequin that completed up over $2,000 on its FBS faculty soccer picks since its inception, and discover out.



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