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NFL picks for Week 16, rating predictions, finest bets at present from self-learning AI

Madisony
Last updated: December 19, 2025 3:39 pm
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NFL picks for Week 16, rating predictions, finest bets at present from self-learning AI
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High Week 16 NFL AI picksHow to make Week 16 NFL picks

The Week 16 NFL schedule options 16 extra video games, together with a number of with potential playoff ramifications. One such recreation is a Saturday NFC North battle between the Inexperienced Bay Packers (9-4-1) and the Chicago Bears (10-4). Chicago is favored by 1.5 factors as Jordan Love and the Packers face Caleb Williams and the Bears. Inexperienced Bay has gained 9 of the previous 10 conferences, together with a 28-21 victory at Lambeau Subject two weeks in the past. One other key matchup between two contenders is the NFC South matchup between the division co-leading Carolina Panthers and Tampa Bay Buccaneers. The groups are tied with 7-7 information and play one another two instances within the last three weeks. 

The Buccaneers enter as 3-point street favorites. Sunday’s largest spreads embrace Raiders vs. Texans (-14.5), Payments (-10.5) vs. Browns and Steelers vs. Lions (-7). Among the many worst accidents suffered in Week 15 embrace Patrick Mahomes (knee) of the Chiefs and Micah Parson (knee) of the Packers, which have affected the NFL spreads of their respective video games. Earlier than making any Week 16 NFL picks or NFL rating predictions on these video games or others, you should see the NFL towards the unfold, over/underneath and cash line predictions powered by the self-learning SportsLine AI.

Constructed utilizing cutting-edge synthetic intelligence and machine studying methods by SportsLine’s Information Science workforce, AI Predictions and AI Scores are generated for every recreation. The AI predictions are decided by statistically studying from every workforce’s historic knowledge after which quantitatively evaluating the energy of the opponent’s protection by assigning a numeric worth out of 100 known as a matchup rating. It constantly refreshes on the newest accessible knowledge and may also help you notice the largest discrepancies within the strains. SportsLine’s AI PickBot has hit greater than 2,000 4.5- and 5-star prop picks for the reason that begin of the 2023 season. 

For Week 16 NFL betting, SportsLine AI has evaluated the NFL odds and supplied NFL betting picks for all 16 video games. You’ll be able to solely see the AI predictions for the Week 16 NFL schedule right here.

High Week 16 NFL AI picks

After analyzing each recreation in Week 16, the AI says the Broncos (-3.5, 46.5), who’ve gained 11 in a row, cowl comfortably towards the Jaguars. 

The Broncos have gone over in every of their final 4 video games, whereas the over has hit in every of the final two Jaguars video games. Guess the Over 45.5 within the newest DraftKings promo code, which gives $200 in bonus bets in case your first guess wins:

Denver is looking for its 12th win in a row and is expected to win comfortably over the AFC South-leading Jaguars. A win will move the Broncos closer to clinching the AFC West title. SportsLine AI rates the Broncos as an A+ spread pick and also predicts a 27-20 win on average. See its other Week 16 football predictions and football picks at SportsLine, and bet the Broncos at DraftKings here:

How to make Week 16 NFL picks

In addition, the AI PickBot has generated more than two dozen highly-coveted A picks for Week 16. You need to see the AI’s NFL picks before making any Week 16 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 16 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.



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