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NFL Week 2 odds, predictions, knowledgeable picks: Greatest bets, teasers, survivor picks, unfold, the place to observe, stream

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Last updated: September 14, 2025 11:23 am
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NFL Week 2 odds, predictions, knowledgeable picks: Greatest bets, teasers, survivor picks, unfold, the place to observe, stream
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Contents
Jaguars at BengalsGiants at CowboysBears at LionsRams at TitansPatriots at Dolphins49ers at SaintsPayments at JetsSeahawks at SteelersBrowns at RavensBroncos at ColtsPanthers at CardinalsEagles at ChiefsFalcons at VikingsBuccaneers at TexansChargers at Raiders

One other week, one other spherical of must-see matchups throughout the NFL. One week after some beautiful developments, like Daniel Jones torching the Miami Dolphins and Justin Herbert stepping up in crunch time to finest the Kansas Metropolis Chiefs, we have one other slate filled with intriguing motion in Week 2.

As we’ll do each week all through the season, we have collected the entire finest picks and playing content material from CBS Sports activities and SportsLine and put them in a single place. That approach, you may get picks in opposition to the unfold from our CBS Sports activities specialists in addition to extra characteristic content material for every recreation, together with performs from high SportsLine specialists and the SportsLine Projection Mannequin, finest bets from our workers, survivor picks and extra. Prepared? Let’s leap in.

Wager NFL Week 2 video games and NFL odds at DraftKings, the place new customers get $200 in bonus bets and over $200 off NFL Sunday Ticket. Click on right here to get began:

All NFL odds through SportsLine consensus odds. Which picks are you able to make with confidence in Week 2? And which Tremendous Bowl contender goes down onerous? Go to SportsLine, as its unbelievable mannequin simulates each NFL recreation 10,000 occasions and is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception.

Jaguars at Bengals

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Bengals -3.5: “The excellent news for the Bengals is that Joe Burrow threw for 113 yards (in Week 1) and in case you’re questioning why that is excellent news, it is as a result of Burrow virtually by no means performs two unhealthy video games in a row. The Bengals quarterback has been held beneath 200 yards passing a complete of 14 occasions in his profession and here is what he is performed within the following recreation: He is averaged 298.4 passing yards, 2.1 landing passes and simply 0.6 interceptions. … [Now] he will get to go up in opposition to a Jaguars protection that surrendered probably the most passing yards within the NFL final season.” — CBS Sports activities NFL author John Breech on why he has the Bengals beating the Jaguars, 27-20, in his Week 2 picks.

You’ll be able to wager Bengals vs. Jaguars at FanDuel, the place new customers get $300 in bonus bets with a profitable $5 wager. Click on right here to get began.

Giants at Cowboys

Sunday, 1 p.m. ET on Fox | Stream: Fubo (Strive totally free)

Giants +6: “I am not fairly positive why Brian Daboll did not pull the plug on the Russell Wilson experiment after Week 1. The earlier New York can play rookie Jaxson Dart at quarterback, the higher for New York’s offense long run. Perhaps Wilson is in danger for an in-game benching on Sunday? I’ll predict that occurs and the Giants stage a late comeback within the second half however fall quick. I strongly lean Dallas at residence, however I might be hesitant to put the six factors.” — SportsLine knowledgeable Eric Cohen, who went 12-4 in Week 1 bets, on why he likes the Cowboys to assert a 27-23 victory over the rival Giants on Sunday. Take a look at all his final-score predictions proper right here.

Bears at Lions

Sunday, 1 p.m. ET on Fox | Stream: Fubo (Strive totally free)

The SportsLine simulation mannequin has scoured Week 2 NFL odds and locked in 5 assured finest bets. If you happen to efficiently parlay its sports activities betting picks, you would be taking a look at a payout of round 24-1. One decide the mannequin is prepared to provide away: The Lions (-5.5) cowl in opposition to the Bears properly over 60% of the time, even after struggling to maintain tempo with the Inexperienced Bay Packers in a season-opening loss at Lambeau Subject. Get the complete forecast proper right here.

Rams at Titans

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Titans +5.5: “The Titans confirmed properly on protection final week, which can make this fascinating for a Rams offense that did not do a lot of their victory over the Texans. Tennessee’s offense struggled, too, however now Cam Ward is residence after shedding at Denver. I feel he’ll play higher, nevertheless it’s the protection that retains the Titans in it. Rams will win a detailed one.” — CBS Sports activities senior NFL columnist Pete Prisco on why he has Tennessee masking at residence in opposition to Matthew Stafford and the Rams. To see all of Prisco’s Week 2 picks, click on right here.

Patriots at Dolphins

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Patriots +1.5: “This has extra to do with the Dolphins than the rest. We knew the protection, significantly the secondary, would battle amid all of the turnover and accidents on that facet of the ball. The energy was speculated to be the offense; nevertheless, it seemed atrocious in Week 1. … The Patriots did not impress of their season opener, significantly with their second-half dud in opposition to Las Vegas. Nevertheless, this Miami protection presents Drake Maye and Co. with the right get-right spot.” — CBS Sports activities NFL author Tyler Sullivan on why he is acquired New England claiming a 24-20 victory within the AFC East. Take a look at all of his Week 2 picks proper right here.

Wager video games like Dolphins vs. Patriots at BetMGM, the place new customers rise up to $1,500 again in bonus bets if their first wager would not win. Get began now:

49ers at Saints

Sunday, 1 p.m. ET on Fox | Stream: Fubo (Strive totally free)

Saints +4.5: The SportsLine mannequin is shying away from selecting the 49ers (-4.5) over the Saints for survivor swimming pools, though the 49ers are coming off a 17-13 win at Seattle on Sunday. Two prices coming from that victory have been accidents to quarterback Brock Purdy and tight finish George Kittle. Purdy suffered shoulder and toe accidents and his standing is unsure, whereas Kittle reportedly will miss a number of weeks with a hamstring damage. The mannequin favors the Saints to win in 41% of simulations, making the 49ers an uneasy choice. Take a look at the full breakdown right here.

Payments at Jets

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Payments -6.5: SportsLine’s pc simulation mannequin may return greater than $6,000 for a $10 bettor on top-rated Week 2 picks. One of many notable bets this weekend: The Payments are featured in a 5-leg parlay, listed as -6.5 favorites on the usual unfold but in addition masking the alternate unfold of -12.5 in opposition to the rival Jets, returning +172. The parlay additionally consists of 4 different picks from the SportsLine mannequin, together with two first landing scorer props that each return +450 or greater. Take a look at SportsLine’s full slate of longshot betting choices proper right here.

Seahawks at Steelers

Sunday, 1 p.m. on Fox | Stream: Fubo (Strive totally free)

Steelers -3: “The Steelers are taking part in the house opener in opposition to a Seattle crew that misplaced a troublesome one to the 49ers final week. Aaron Rodgers seemed good in opposition to the Jets and I feel that may carry over right here. The Steelers will go to 2-0 as Rodgers performs properly and DK Metcalf does some harm to his former crew.” — Prisco on why he likes Pittsburgh to remain unbeaten with a 26-19 victory over the Seahawks. Take a look at all of his Week 2 picks proper right here.

Browns at Ravens

Sunday, 1 p.m. on CBS | Stream on Paramount+

“[One] large favourite can be calling survivor individuals within the Ravens. Baltimore suffered its newest meltdown on Sunday because the Payments scored 16 factors within the closing 4 minutes to win by one, leaving the Ravens with a nasty style of their mouth heading into a gathering with the Browns on Sunday. The Ravens are double-digit favorites in that recreation, whereas no different crew is laying even a landing as of writing, so we may see a large pile-on in survivor swimming pools with many choosing the Ravens. Nevertheless, these in 20-game-week codecs that make Thanksgiving and Christmas their very own slates should weigh shedding the Ravens from that first mini-slate.” — SportsLine knowledgeable R.J. White, who’s up greater than 32 models on ATS picks over the past eight years, on Week 2 survivor-pool bets.

Broncos at Colts

Sunday, 4:05 p.m. on CBS | Stream on Paramount+

Colts +2.5: “I do not need to say that we have been all flawed about Daniel Jones, however we’d have all been flawed about Daniel Jones. You understand how generally individuals are approach higher off after a breakup? Nicely, that is Jones leaving the Giants. Apparently, all he wanted was an opportunity to play for any crew apart from them. In his first recreation with Indianapolis, the Colts had the ball seven occasions they usually scored on all seven possessions.”  — John Breech on Indy probably proudly owning a shock quarterback benefit as he favors the Colts in his Week 2 predictions. 

Panthers at Cardinals

Sunday, 4:05 p.m. on CBS | Stream on Paramount+

Cardinals -6.5: The SportsLine mannequin, which simulates each NFL recreation 10,000 occasions, is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin can be on a 33-17 run on top-rated picks relationship again to 2024. Considered one of its high Week 2 bets: the Cardinals (-6.5, 45.5) cowl at residence versus the Panthers in virtually 60% of simulations. The mannequin additionally says the Over hits virtually 60% of the time, regardless of Carolina struggling to search out an offensive rhythm in opposition to the Jacksonville Jaguars in a season-opening loss. Get all of the mannequin’s Week 2 picks.

Eagles at Chiefs

Sunday, 4:25 p.m. on Fox | Stream: Fubo (Strive totally free)

Eagles -1.5: “Typical knowledge says to not wager in opposition to Patrick Mahomes, particularly when he is something near an underdog. In video games the place he isn’t favored by greater than three factors, the Chiefs QB is 20-7-1 ATS. Even with that data, we’re fading Kansas Metropolis anyway. With Xavier Worthy (shoulder) sidelined and Rashee Rice nonetheless suspended, I am unsure the Chiefs have the firepower to match the Eagles on this Tremendous Bowl LIX rematch. Philadelphia’s protection did not wow me within the opener in opposition to Dallas, however … with Jalen Carter again within the fold, I anticipate the Eagles protection to look an entire lot higher and assist the crew exit Arrowhead 2-0.” — CBS Sports activities NFL author Tyler Sullivan on why he is betting in opposition to the Chiefs. Discover Sully’s full Week 2 predictions proper right here.

Falcons at Vikings

Sunday, 8:20 p.m. on NBC | Stream: Fubo (Strive totally free)

Earlier than you wager on J.J. McCarthy’s return to prime time for a matchup with the Falcons, you will need to take into account what SportsLine knowledgeable R.J. White has to say in regards to the contest. R.J. is 63-32-5 (+2792) in his final 100 picks involving the Vikings, so he is particularly in tune with what to anticipate from Minnesota. Can McCarthy get a second straight win to open his profession because the Vikings’ quarterback? Take a look at the complete ATS prediction over at SportsLine.

Buccaneers at Texans

Monday, 7 p.m. ET on ABC/ESPN | Stream: Fubo (Strive totally free)

The Buccaneers survived the Falcons in Week 1, whereas the Texans had few solutions for the Rams, at the least on offense. Will the house crowd be sufficient to get C.J. Stroud and Co. again on observe? Or is Baker Mayfield primed for an additional gutsy efficiency on the highway? SportsLine knowledgeable Micah Roberts has a solution for you, and he is acquired the observe file to warrant your consideration, going 20-9-1 (+1013) in his final 30 picks involving Tampa Bay. Take a look at his full breakdown of this Monday evening matchup, full with an ATS prediction, over at SportsLine.

Chargers at Raiders

Monday, 10 p.m. ET on ESPN | Stream: Fubo (Strive totally free)

Maybe no NFL crew had a greater begin to 2025 than the Chargers, who noticed Justin Herbert unleash one in every of his most interesting performances to knock off the rival Chiefs in Brazil. Is it secure to wager on the upstart Bolts on the highway, with the Raiders set to host the second of two Monday evening matchups? SportsLine knowledgeable Mike Tierney, who’s 13-4 (+865) on his final 17 picks involving Las Vegas, has an in depth ATS prediction proper right here.



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