The primary month of the season is when each membership will get its toes moist and settles into the 12 months. As for the second month, that is when groups start to separate themselves as both a playoff contender or somebody already waiting for 2026. Week 6 has loads of intriguing matchups on deck, and already is off the heels of the New York Giants upsetting the Philadelphia Eagles on Thursday evening. That simply goes to indicate you that something can unfold after kickoff, so you may need to be in- sync with all of the motion.
As we do each week all through the season, we have collected all the greatest picks and playing content material from CBS Sports activities and SportsLine and put them in a single place, so you will get picks towards the unfold from our CBS Sports activities specialists in addition to extra characteristic content material for every sport, together with performs from high SportsLine specialists and the SportsLine Projection Mannequin, greatest bets from our employees, survivor picks and extra. Prepared? Let’s bounce in.
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Broncos at Jets (in London)
Sunday, 9:30 a.m. ET on NFL Community (Stream: Fubo — attempt without spending a dime)
Broncos -7.5: “One of many extra stunning components of the Jets poor begin to the season is that they’ve but to document a single turnover, which is blasphemous for an Aaron Glenn-led group. If that continues, Bo Nix and the Broncos offense should not have any drawback entering into the tip zone no less than 3 times. In the event that they do, that will virtually routinely safe them the win. In his profession, Justin Fields is 0-26 when his opponent scores 21 or extra factors. For reference, Denver is averaging 23.4 factors per sport. In the meantime, favorites of seven or extra factors are 8-2 ATS all time in worldwide video games, in order that’s one other feather in our cap right here.” — CBS Sports activities NFL author Tyler Sullivan on why he has Denver overlaying in London. To see the remainder of his Week 6 picks, click on right here.
Cardinals at Colts
Sunday, 1 p.m. ET on Fox (Stream: Fubo — attempt without spending a dime)
The SportsLine Projection Mannequin has been a go-to supply all through the 2025 season and has traditionally been a worthwhile device for bettors. The mannequin, which simmulates each NFL sport 10,000 occasions, is up nicely over $7,000 for $100 gamers on top-rated NFL pciks since its inception. It has additionally gone 4-1 relationship again to 2024 with its high survivor swimming pools. For Week 6, we will let you know the mannequin has the Indianapolis Colts successful in 70% of simulations. Whereas that is a stable quantity, the mannequin additionally has a play that’s successful in 79% of sims. To test that out, head on over to SportsLine.
Colts -6.5: “The Cardinals have given up the fifth-most passing yards within the NFL this 12 months, though they’ve confronted one of many simpler QB slates. … Daniel Jones would possibly throw for 600 yards. Heading into Week 6, the Colts are the one group I am nonetheless excellent selecting this 12 months: I am 5-0 straight-up and 5-0 towards the unfold selecting their video games, and after a disastrous Week 5, they’re the one group I am assured in selecting. There is no such thing as a method the Cardinals are going to be mentally recovered from struggling essentially the most inexplicable collapse in NFL historical past. I imply, I did not even play within the sport and I am not mentally recovered.” — CBS Sports activities NFL author John Breech on why he likes the Colts to cowl towards Arizona. To see the remainder of his Week 6 picks, click on right here.
Browns at Steelers
Sunday, 1 p.m. ET on CBS (Stream on Paramount+)
Steelers -5.5: “We speak lots about how Mike Tomlin has by no means had a shedding season as coach of the Pittsburgh Steelers. That is definitely spectacular, however as we take a look at this upcoming matchup towards the Cleveland Browns, we’re highlighting one other Tomlin-specific stat. The coach is 26-6 straight up in his profession towards rookie quarterbacks. That is the second-best document by a coach with no less than 15 video games since 1970. Historical past tells us he should not have any drawback diluting Dillon Gabriel’s effectiveness on this sport, and Pittsburgh’s 10 takeaways this season (second-most within the NFL) solely emboldens us to put the factors on this spot. Do not look now, however T.J. Watt can be beginning to warmth up with three sacks within the final two video games. That is even worse information for Gabriel.” — CBS Sports activities NFL author Tyler Sullivan on why he has Pittsburgh pulling out the win over Cleveland. To see all of his Week 6 picks, click on right here.
Cowboys at Panthers
Sunday, 1 p.m. ET on Fox (Stream: Fubo — attempt without spending a dime)
Cowboys -3.5: “The Cowboys are enjoying consecutive street video games, however they’re rolling on offense with Dak Prescott. The Panthers got here again to beat Miami final week, however slowing Prescott will probably be an enormous problem. Search for the Cowboys offense to proceed to roll as their protection continues to enhance. Dallas wins it.” — CBS Sports activities Senior NFL analyst Pete Prisco on why he has Dallas beating Carolina, 30-21. To see all of his Week 6 picks, click on right here
Which picks are you able to make with confidence in Week 5? And which Tremendous Bowl contender goes down onerous? Go to SportsLine, as its unimaginable mannequin simulates each NFL sport 10,000 occasions and is up nicely over $7,000 for $100 gamers on top-rated NFL picks since its inception.
Chargers at Dolphins
Sunday, 1 p.m. ET on CBS (Stream on Paramount+)
Chargers -4.5: “Dolphins followers will probaly be much more regretful in regards to the resolution when Herbert throws his third landing cross on Sunday, which I thnk goes to occur. Herbert positively has the extra favorable matchup since he’ll be going up towards a Dolphins protection that’s surrendering a 117.6 passer ranking to opposing quarterbacks. To place that in perspective, the best profession passer ranking by any QB in NFL historical past is 103. On common, the Dolphins are letting opposing quarterbacks do 14 factors higher than that in each sport. On the flip facet, opposing quarterbacks solely have a 77.3 passer ranking towards the Chargers, so do not be shocked if Tua struggles some on this sport.” — CBS Sports activities NFL author John Breech on why he likes the Chargers to cowl on the street towards Miami. To see the remainder of his Week 6 picks, click on right here.
Rams at Ravens
Sunday, 1 p.m. ET on Fox (Stream: Fubo — attempt without spending a dime)
Rams -7.5: “The Ravens are a large number, whereas the Rams are coming off a foul loss to the 49ers at dwelling. The Ravens will seemingly be with out Lamar Jackson once more, and the banged-up protection cannot cease anyone. The Rams protection did not play nicely towards the 49ers, however will right here. Rams take it.” — CBS Sports activities Senior NFL analyst Pete Prisco on why he has the Rams overlaying in Baltimore. To see all of his Week 6 picks, click on right here
Patriots at Saints
Sunday, 1 p.m. ET on CBS (Stream on Paramount+)
Saints +3.5: “The Patriots are using excessive after beating the Payments on Sunday evening, however this will probably be a tricky sport coming off that large victory. The Saints beat the Giants final week as Spencer Rattler and the protection performed large. This will probably be a problem for the Patriots and Drake Maye. It is shut, however Maye will win it late.” — CBS Sports activities Senior NFL analyst Pete Prisco on why the Patritos will edge out a 22-21 win in New Orleans. To see all of his Week 6 picks, click on right here.
Seahawks at Jaguars
Sunday, 1 p.m. ET on Fox (Stream: Fubo — attempt without spending a dime)
Seahawks +1.5: “Whereas Jacksonville is among the extra stunning tales of the 2025 season up to now with a 4-1 document, I nonetheless have loads of questions on them, notably surrounding Trevor Lawrence. He is twenty fourth amongst 33 certified quarterbacks this season in EPA per dropback, and largely did his injury on Monday evening together with his legs. The passing left little to be desired outdoors of a few late throws to tug off the upset. The Jags are one of many high dashing offenses within the NFL, however that performs right into a key power of the Seahawks. Seattle is giving up 3.3 yards per carry this season, which is second-best within the NFL. If that continues and so they plug up the working lanes for Jacksonville, Lawrence’s passing deficiencies may very well be uncovered.” — CBS Sports activities NFL author Tyler Sullivan on why he has Seattle pulling off the street win in Jacksonville. To see all of his Week 6 picks, click on right here.
Titans at Raiders
Sunday, 4:05 p.m. on Fox (Stream: Fubo — attempt without spending a dime)
Titans +4.5: “If in case you have a gifted working again, he ought to have the ability to discover room to run towards the Titans and the Raiders have Ashton Jeanty, who’s averaged practically 90 yards per sport over the previous three weeks. With Smith struggling, Jeanty will in all probability be an enormous a part of the sport plan this week, or the one half. If the Raiders are sensible, they will simply let him carry the ball 57 occasions. This seems like a sport the Raiders ought to win, however I additionally thought that final week when the Cardinals performed the Titans and NOW I’M OUT OF MY SURVIVOR POOL FOR THAT, so what do I do know. Have I discussed that I hate survivor swimming pools?” — CBS Sports activities NFL author John Breech on why he has the Titans overlaying, however the Raiders pulling off the outright win. To see his full evaluation and different Week 6 picks, click on right here.
Bengals at Packers
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Bengals +14.5: “The Bengals have main offensive points with Jake Browning enjoying quarterback, which is why they traded for Joe Flacco. Whoever performs quarterback is on the street towards a great Packers protection coming off a bye. This will probably be ugly for the Bengals once more as Inexperienced Bay wins it, because of a protection that did not play nicely the final day trip.” — CBS Sports activities Senior NFL analyst Pete Prisco on why he has the Packers beating the Bengals, 31-17. To see all of his Week 6 picks, click on right here.
49ers at Buccaneers
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Buccaneers -3: “The 49ers are rested after enjoying final Thursday, which is able to assist the injured. They upset the Rams, whereas Tampa Bay beat Seattle behind Baker Mayfield final week. Mac Jones performed nicely for the 49ers, however Mayfield and the Bucs are on a sizzling streak. They’ll hold it rolling.” — CBS Sports activities Senior NFL analyst Pete Prisco on why he likes the Bucs to tug off the 30-20 win over the Niners. To see all of his Week 6 picks, click on right here.
Lions at Chiefs
Sunday, 8:20 p.m. on NBC (Stream: Fubo — attempt without spending a dime)
SportsLine’s R.J. White is a guru with regards to betting on the NFL and is at present on a 33-20 roll with Detroit Lions video games. Naturally, you may need to see which method he is leaning for this Sunday Night time Soccer matchup, notably together with his official decide coming as a little bit of a shock. We are able to let you know White is leaning Beneath 53, however to see that official picks, you may have to go to SportsLine.
Lions +2.5: “The Lions have gained 4 straight video games after shedding the season opener to the Inexperienced Bay Packers, which is definitely the longest lively win streak within the NFL. Detroit is averaging 40.3 factors per contest over this four-game stretch. Is anybody lacking Ben Johnson but? Enjoying in Arrowhead is hard, and the Chiefs positively gained the “battle of the damage stories” on Wednesday. Kansas Metropolis had full attendance, whereas Terrion Arnold, Zach Cunningham, Taylor Decker, Kerby Joseph and Amon-Ra St. Brown missed observe. Nonetheless, Jared Goff is one in every of simply two gamers to beat Mahomes a number of occasions whereas having zero losses to him (the opposite is Ryan Tannehill), and I imagine the Lions can simply merely outscore the Chiefs. However I am extra snug taking the Over.” — CBS Sports activities’ Jordan Dajani on why he has the Lions not solely overlaying however pulling off the upset over Kansas Metropolis. To see all of his greatest bets, click on right here.
Payments at Falcons
Monday, 7:15 p.m. on ESPN (Stream: Fubo — attempt without spending a dime)
SportsLine skilled Zack Cimini, who was 35-25-4 on his NFL picks in 2024, has dialed in his decide for the primary leg of Monday’s double-header. Cimini is somebody you may need to lean on for this matchup as he’s 17-4 (+1260) in his final 21 choices involving the Falcons. We are able to let you know he is leaning Beneath the 50 level complete, however to see his official play for this sport, go take a look at SportsLine.
Payments -4.5: “As identified by one in every of their beat writers, the Falcons are the one group within the NFL that has restricted all of their opponents to lower than 300 yards of complete offense this 12 months. The Payments, in the meantime, are the one group within the NFL to have totaled no less than 300 yards of offense in each sport they’ve performed this season. One thing’s received to provide right here, and I am extra inclined to provide it to a Payments group that continues to be excellent regardless of a detailed loss in a division sport every week in the past in comparison with a .500 Falcons group coming off a bye.” — CBS Sports activities’ Steve Taranto on why he likes Buffao to cowl on the street. To see his Week 6 picks, click on right here.
Bears at Commanders
Monday, 8:15 p.m. ET on ABC(Stream: Fubo — attempt without spending a dime)
You do not need to miss what SportsLine skilled Mike Tierney thinks of this sport between the Commanders and Bears. Tierney has been on level in video games involving Chicago, proudly owning a 31-17-2 document in his final 50 Bears picks. We are able to let you know Tierney is leaning Beneath the full, however to see is official unfold decide, you may want to go browsing to SportsLine.
Bears +4.5: “This sport matches Caleb Williams vs. Jayden Daniels, the 2 high picks within the 2024 NFL Draft. They met final 12 months in a sport gained on a Hail Mary by Daniels. The Bears are coming off a bye and two straight victories, however this sport will probably be gained by Daniels outplaying Williams. Commanders take it.” — CBS Sports activities Senior NFL analyst Pete Prisco on why he likes Washington to win however not cowl. To see all of his Week 6 picks, click on right here.
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