The 2025 NFL common season kicks off on Thursday, with the defending Tremendous Bowl champion Philadelphia Eagles (-8.5) internet hosting the Dallas Cowboys within the 2025 NFL Kickoff Recreation. Week 1 spans Thursday by way of Monday, highlighted by a Friday worldwide matchup in São Paulo between the Kansas Metropolis Chiefs (-3) and Los Angeles Chargers, and a Sunday Evening Soccer showdown that includes the Baltimore Ravens towards the Buffalo Payments (-1.5). The opening weekend additionally options heavyweight matchups just like the Lions (-2.5) vs. Packers and 49ers (-2.5) vs. Seahawks.
Who must you again in every of the 16 video games on the Week 1 NFL schedule, and the way must you deal with all of your NFL cash line, NFL over/underneath and NFL towards the unfold unfold picks? Earlier than making any Week 1 NFL picks or Week 1 NFL rating predictions, you’ll want to see the NFL towards the unfold, NFL over/underneath, and NFL money-line predictions powered by the SportsLine laptop simulation mannequin.
The mannequin, which simulates each NFL recreation 10,000 occasions, is up nicely over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin went 31-15 on top-rated picks in 2024. Anybody following has seen enormous returns.
For Week 1 NFL betting, the mannequin has evaluated the NFL odds and supplied picks for all 16 video games. You’ll be able to solely see the simulation mannequin’s predictions for the Week 1 NFL schedule right here. Additionally, may goal the DraftKings promo code, which gives $300 in bonus bets immediately plus over $200 off NFL Sunday Ticket:
Prime Week 1 NFL simulation picks
After analyzing each recreation in Week 1, the mannequin says the Commanders cowl comfortably as 6-point dwelling favorites towards the Giants on Sunday in a recreation the mannequin initiatives will go Over the full (45.5) in almost 70% of simulations. The Commanders are coming off a shock run to the NFC Championship Recreation final yr, and enter the 2025 season with championship expectations. DraftKings Sportsbook lists Washington with a projected common season win complete of 9.5.
The Commanders are paced by one of many high younger quarterbacks within the NFL in Jayden Daniels. The reigning NFL Offensive Rookie of the Yr was excellent in 2025, and Washington gave him one other explosive weapon throughout the offseason in All-Professional vast receiver Deebo Samuel. Defensively, the Commanders additionally boast one of many premier entrance sevens within the league — a bunch that was bolstered by the offseason addition of Tremendous Bowl 50 MVP Von Miller. See its different Week 1 predictions and soccer picks at SportsLine.
The way to make Week 1 NFL laptop picks
As well as, the mannequin has generated three different highly-coveted A-graded picks for Week 1, which incorporates an underdog successful outright on the moneyline. You’ll be able to solely see the mannequin’s picks and evaluation at SportsLine.
Who wins and covers every Week 1 NFL recreation, and which A-graded picks must you goal now? Go to SportsLine now to see the highest NFL towards the unfold, over/underneath, and moneyline picks, all from the pc simulation mannequin that’s up over $7,000 since its inception, and discover out.
