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NFL Week 12 picks, predictions, odds, greatest bets and survivor performs for every recreation

Madisony
Last updated: November 21, 2025 6:16 pm
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NFL Week 12 picks, predictions, odds, greatest bets and survivor performs for every recreation
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Contents
Steelers at BearsPatriots at BengalsGiants at LionsVikings at PackersSeahawks at TitansColts at ChiefsJets at RavensBrowns at RaidersJaguars at CardinalsEagles at CowboysFalcons at SaintsBuccaneers at RamsPanthers at 49ers

One other week, one other spherical of must-see matchups is on faucet throughout the NFL. Week 11 introduced loads of stunners, together with the Jacksonville Jaguars routing the Los Angeles Chargers and the Bo Nix-led Denver Broncos outdueling the Kansas Metropolis Chiefs. Now we have got one other slate filled with intriguing motion in Week 12.

We collected all the most effective picks and playing content material from CBS Sports activities and SportsLine and put them in a single place. That approach you may get picks towards the unfold from our CBS Sports activities specialists in addition to further function content material for every recreation, together with performs from high SportsLine specialists and the SportsLine Projection Mannequin, greatest bets from our employees, survivor picks and extra. Let’s leap in.

NFL odds by way of DraftKings Sportsbook (except in any other case famous). Guess NFL Week 12 video games at DraftKings Sportsbook, the place new customers get $300 in bonus bets and three free months of NBA League Move.

Steelers at Bears

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Steelers +3: The SportsLine simulation mannequin can be utilized for survivor swimming pools, which name for choosing one crew to win every week however by no means utilizing the identical crew twice. This week, the mannequin is shying away from the Bears, who enter as 3-point favorites, having received three in a row. Even with Aaron Rodgers’ standing unsure because of the quarterback struggling a wrist fracture, SportsLine mannequin initiatives Pittsburgh protecting in additional than 50% of simulations, making Chicago a crew to fade. Take a look at the complete breakdown proper right here.

Patriots at Bengals

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Patriots -8.5: “I do not see how Cincinnati retains up. New England is driving an eight-game profitable streak, and Drake Maye is enjoying at an MVP stage, main the NFL in completion share (71.9%) and passing yards (2,836) getting into Week 12. Now, he’ll face off towards a Bengals protection that’s giving up 33.4 factors per recreation this season. That is not solely the best within the league in 2025; it is essentially the most factors per recreation allowed in a season because the 1966 New York Giants.” — CBS Sports activities NFL author Tyler Sullivan on why he likes New England to win large.

Guess video games like Bengals vs. Patriots at BetMGM, the place new customers stand up to $1,500 again in bonus bets if their first guess would not win.

Giants at Lions

Sunday, 1 p.m. ET on Fox | Stream: Fubo (strive totally free)

Lions -10.5: “The Lions are coming off a tricky loss to the Eagles and now should regroup at residence towards a Giants crew that is not going wherever. … This will likely be concerning the Lions’ offense getting again on observe after disappointing final week. They roll.” — CBS Sports activities senior NFL columnist Pete Prisco on why he likes Detroit to rout the G-Males.

Vikings at Packers

Sunday, 1 p.m. ET on Fox | Stream: Fubo (strive totally free)

Packers -6.5: “[The Packers have] persistently performed right down to their competitors … [but] as a lot as I’m skeptical about Inexperienced Bay, I am much more so in the case of J.J. McCarthy. There have been factors final week in Minnesota’s loss to Chicago the place it felt like McCarthy may have been benched. He is finishing simply 52.9% of his passes this season and is the primary quarterback since Zach Wilson (not nice firm) to have an interception in 5 straight video games to start his profession.” — CBS Sports activities NFL author Tyler Sullivan on why he is betting large on the Pack.

Seahawks at Titans

Sunday, 1 p.m. ET on Fox | Stream: Fubo (strive totally free)

Seahawks -13.5: SportsLine AI is the primary totally automated predictive mannequin at SportsLine. It repeatedly refreshes on the latest out there information to establish the largest discrepancies in strains. After analyzing each recreation in Week 12, the AI says the Seahawks (-13.5) cowl comfortably towards the Titans, who’ve misplaced 5 in a row. The mannequin charges the Seahawks as an A+ unfold decide and likewise predicts a 30-14 win on common.

Colts at Chiefs

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Colts +3.5: “I hate selecting towards the Chiefs at residence, however I feel I’ve to do it right here. The Colts have an opportunity to roll into Kansas Metropolis and ship a knockout blow to the Chiefs’ division title probabilities whereas additionally placing their playoff hopes on life assist. The Colts will likely be coming into this recreation off a bye, which signifies that the NFL’s main rusher, Jonathan Taylor, could have had a while to relaxation his legs, and I am guessing he wanted that relaxation, as a result of he ran for 244 yards the final time he was on the sector.” — CBS Sports activities NFL author John Breech on why he likes Indianapolis at hand the reigning AFC champions their third straight loss.

Jets at Ravens

Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Ravens -13.5: The SportsLine Projection Mannequin, which simulates each NFL recreation 10,000 instances, is up effectively over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin additionally enters Week 12 on a 48-33 run on top-rated picks courting again to 2024. We will let you know that one among its strongest bets for this Sunday’s slate includes the Ravens, with Baltimore protecting towards the Jets in additional than 50% of simulations. The Over additionally hits in additional than 80% of simulations for this AFC matchup. Take a look at SportsLine’s full breakdown proper right here.

Browns at Raiders

Sunday, 4:05 p.m. ET on CBS | Stream on Paramount+

Browns +3.5: “Cleveland rookie Shedeur Sanders will be beneath heart for his first profession begin. … [But] actually, it is concerning the Raiders’ offense having to face Cleveland’s protection. The Browns are permitting simply 4.8 yards per play this season, which is the fourth-fewest within the NFL getting into Week 12. Cleveland has additionally pressured 10 takeaways over the previous 4 weeks, and now squares up towards a Las Vegas offense that continues to look misplaced.” — CBS Sports activities NFL author Tyler Sullivan on why he likes the Browns as potential spoilers on the street.

Jaguars at Cardinals

Sunday, 4:05 p.m. ET on CBS | Stream on Paramount+

Jaguars -2.5: “It is a lengthy journey for a crew coming off a giant victory just like the Jaguars did final week towards the Chargers. Focus might be a difficulty with a younger crew, however I nonetheless suppose they discovered one thing on offense final week. That can carry over right here. They get the most effective of an Arizona crew that’s struggling.” — CBS Sports activities senior columnist Pete Prisco on why he likes Jacksonville to win its third recreation in 4 weeks.

Eagles at Cowboys

Sunday, 4:25 p.m. ET on Fox | Stream: Fubo (strive totally free)

The SportsLine Projection Mannequin, which simulates each NFL recreation 10,000 instances, additionally gives Fantasy suggestions, and this week the recommendation is a stunner: Cowboys quarterback Dak Prescott, who’s the QB8 getting into Week 12 and coming off a four-touchdown recreation, might not warrant a spot in Sunday’s Fantasy lineups as he sits outdoors the highest 15 in quarterback rankings. Why? He is up towards a ferocious Eagles protection. However will the Birds additionally come alive offensively to beat Dallas on the street? Take a look at SportsLine’s full evaluation proper right here.

Falcons at Saints

Sunday, 4:25 p.m. ET on Fox | Stream: Fubo (strive totally free)

Falcons +1.5: “That is admittedly a tough spot for Atlanta. They’re driving a five-game shedding streak and can now be with out beginning quarterback Michael Penix Jr. and high wideout Drake London attributable to harm. … Sure, New Orleans could have the remaining benefit coming off of their bye, however that is nonetheless a roster starved for expertise, making this a real coin flip. Kirk Cousins will get the beginning for Atlanta, and whereas he is actually into the again finish of his profession, this can be a recreation the place Bijan Robinson may carry him to victory.” — CBS Sports activities NFL author Tyler Sullivan on why he likes the Falcons as an upset candidate towards the membership’s NFC South rivals.

Buccaneers at Rams

Sunday, 8:20 p.m. ET on NBC | Stream: Fubo (strive totally free)

SportsLine skilled Larry Hartstein has the heart beat of Los Angeles, as he is 26-10 (+1501) on his final 36 against-the-spread picks involving the Rams. So does he like Matthew Stafford, who leads the NFL with 27 landing passes, to outduel Baker Mayfield in a possible NFC playoff preview? Or is he going with Tampa Bay to tug off a street upset at SoFi Stadium? Take a look at Hartstein’s skilled evaluation on this one proper right here at SportsLine.

Panthers at 49ers

Monday, 8:15 p.m. ET on ESPN | Stream: Fubo (strive totally free)

SportsLine skilled Micah Roberts is 18-4 (+1360) on his final 22 against-the-spread picks involving the 49ers. So does he like San Francisco to cruise at residence beneath the “Monday Night time Soccer” lights, with Brock Purdy recent off a dynamic return to the lineup? Or is he driving with Bryce Younger and Rico Dowdle as potential prime-time spoilers? Take a look at Roberts’ skilled evaluation and prediction proper right here at SportsLine. 



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NFL Week 12 picks, predictions, odds, greatest bets and survivor performs for every recreation
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