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And just like that, we’re one round down.
Here’s a look at the odds for the men’s NCAA Tournament winner at DraftKings Sportsbook as of March 21.
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2025-26 Men’s NCAA Tournament winner
Arizona: +340 (bet $10 to win $44 total)
Michigan: +370 (bet $10 to win $47 total)
Duke: +450 (bet $10 to win $55 total)
Florida: +800 (bet $10 to win $90 total)
Houston: +900 (bet $10 to win $100 total)
Illinois: +1800 (bet $10 to win $190 total)
Purdue: +2200 (bet $10 to win $230 total)
UConn: +2500 (bet $10 to win $260 total)
Iowa State: +2800 (bet $10 to win $290 total)
Arkansas: +4000 (bet $10 to win $410 total)
St. John’s: +4000 (bet $10 to win $410 total)
Michigan State: +5000 (bet $10 to win $510 total)
Gonzaga: +5500 (bet $10 to win $560 total)
Vanderbilt: +6500 (bet $10 to win $660 total)
Kansas: +7000 (bet $10 to win $710 total)
Nebraska: +7500 (bet $10 to win $760 total)
Tennessee: +8000 (bet $10 to win $810 total)
Duke opened as the favorite, but after a shaky win over 16-seed Siena in the first round, the Blue Devils dropped to third. In that game, Duke trailed by 11 at half before outscoring Siena by 17 in the second half to secure a 71-65 win.
Next up for Duke is TCU in the second round. The Blue Devils are 11.5-point favorites in that matchup.
The new favorite is Arizona, which put a beatdown on LIU in the first round, winning by 34. The Wildcats will face Utah State in the second round, also as 11.5-point favorites.
Michigan remains second on the board and its odds did not shift after a 21-point win over Howard. It next gets Saint Louis, and the Wolverines opened as 12.5-point favorites ahead of that clash.
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