Pfizer (PFE) earnings This fall 2025

Pfizer on Tuesday reported fourth-quarter outcomes that topped estimates even amid dwindling demand for its Covid merchandise, whereas reaffirming its modest 2026 steering that rattled traders in December.

The pharmaceutical big is trying to longer-term investments in its pipeline, together with its $10 billion acquisition of the weight problems biotech Metsera, to counter waning Covid product gross sales and declines from older medicine. Pfizer moved to indicate the promise of that funding Tuesday, when it additionally reported mid-stage knowledge displaying that an weight problems injection from Metsera will be taken as soon as a month and drive stable weight reduction.

As well as, Pfizer is on observe to chop prices by about $7.7 billion by the tip of 2027 as a part of two separate initiatives.

This is what the corporate reported for the fourth quarter in contrast with what Wall Avenue was anticipating, based mostly on a survey of analysts by LSEG: 

• Earnings per share: 66 cents adjusted vs. 57 cents anticipated
• Income: $17.56 billion vs. $16.95 billion anticipated

Pfizer reported income of $17.56 billion for the fourth quarter, down round 1% from the identical interval a yr in the past. That’s largely due to decrease demand for its Covid vaccine and Paxlovid, an antiviral capsule for the virus.

The corporate booked a web lack of $1.65 billion, or 29 cents per share. That compares with web revenue of $410 million, or 7 cents per share, throughout the identical interval a yr in the past.

Excluding sure objects, together with restructuring fees and prices related to intangible belongings, the corporate posted earnings per share of 66 cents for the quarter.

Pfizer expects 2026 adjusted revenue to return in between $2.80 and $3 per share, and income to complete $59.5 billion to $62.5 billion. These gross sales would largely be flat in contrast with 2025 income.

Pfizer beforehand stated the lackluster income outlook is available in half from declining gross sales of its Covid vaccine and antiviral capsule Paxlovid, which it expects to fall by about $1.5 billion yr over yr to $5 billion. 

The corporate additionally pointed to a different roughly $1.5 billion year-over-year anticipated drop in gross sales on account of sure merchandise dropping their market exclusivity. Some blockbuster medicine, comparable to the corporate’s pneumonia vaccine Prevnar, are going through extra competitors from rivals.

In December, Pfizer CFO Dave Denton advised traders there may be additionally “worth compression and margin compression baked into” the corporate’s 2026 steering because it plans to supply “deeper reductions” in its Medicaid enterprise as a part of a landmark drug pricing deal struck with President Donald Trump. 

Below that settlement, Pfizer agreed to promote its present medicine to Medicaid sufferers on the lowest worth provided in different developed nations and assure the identical “most-favored-nation” pricing on its new medicine for Medicare, Medicaid and industrial payers. In return, the corporate will get a three-year exemption from tariffs. 

Pfizer’s Xeljanz and Xeljanz XR, therapies for rheumatoid arthritis and different inflammatory circumstances, had been chosen in January for the third spherical of Medicare drug worth negotiations. New negotiated costs will come into impact in 2028.